BDBM518428 6-[1-[2-[(3R,4R)-3,4- Dihydroxypyrrolidin-1-yl]-2-oxo- ethyl]pyrazol-4-yl]-2-[(2S)-2- methylazetidin-1-yl]-4- (trifluoromethyl)pyridine-3- carbonitrile::US11124500, Example 22

SMILES C[C@H]1CCN1c1nc(cc(c1C#N)C(F)(F)F)-c1cnn(CC(=O)N2C[C@@H](O)[C@H](O)C2)c1

InChI Key InChIKey=FZDYDDBXXVCRTR-YMRXKLBXSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 518428   

TargetIsoform A of Ketohexokinase (Peripheral)(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM518428(6-[1-[2-[(3R,4R)-3,4- Dihydroxypyrrolidin-1-yl]-2-...)
Affinity DataIC50:  33.7nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKetohexokinase(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM518428(6-[1-[2-[(3R,4R)-3,4- Dihydroxypyrrolidin-1-yl]-2-...)
Affinity DataIC50:  61.3nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent