BDBM521255 3-(6-ethoxy-2- fluoro-3- pyridyl)-4-[6- [(3S)-1-(3- fluoropropyl)pyr- rolidin-3-yl]oxy- 3-pyridyl]-2H- thiochromen-7- ol::US11149031, Example 79

SMILES CCOc1ccc(C2=C(c3ccc(O[C@H]4CCN(CCCF)C4)nc3)c3ccc(O)cc3SC2)c(F)n1

InChI Key InChIKey=SVMCHBMPCGATKT-FQEVSTJZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521255   

TargetEstrogen receptor [298-554](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521255(3-(6-ethoxy-2- fluoro-3- pyridyl)-4-[6- [(3S)-1-(3...)
Affinity DataIC50:  0.5nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [298-554,Y537S](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521255(3-(6-ethoxy-2- fluoro-3- pyridyl)-4-[6- [(3S)-1-(3...)
Affinity DataIC50:  5nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [298-554,D538G](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521255(3-(6-ethoxy-2- fluoro-3- pyridyl)-4-[6- [(3S)-1-(3...)
Affinity DataIC50:  6nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent