BDBM525429 US11174245, # I-012

SMILES CC(C)Cn1c2ccccc2[nH]\c1=N/C(=O)c1ccnc(c1)-c1cnn(C)c1

InChI Key InChIKey=XXAOZNYOAOEUOS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 525429   

TargetEpidermal growth factor receptor [695-745,751-1022,T790M,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525429(US11174245, # I-012)
Affinity DataIC50:  10.5nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525429(US11174245, # I-012)
Affinity DataIC50:  1.90nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [695-1022](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525429(US11174245, # I-012)
Affinity DataIC50: >1.00E+5nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [695-1022](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525429(US11174245, # I-012)
Affinity DataIC50:  403nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525429(US11174245, # I-012)
Affinity DataIC50:  64.6nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent