BDBM525492 US11174245, # I-145

SMILES Cn1cc(cn1)-c1cc(cc(n1)C#N)C(=O)\N=c1/[nH]c2cc(CN3CCOCC3)ccc2n1[C@@H]1CC[C@H](O)CC1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 525492   

TargetEpidermal growth factor receptor [695-1022](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525492(US11174245, # I-145)
Affinity DataIC50:  397nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525492(US11174245, # I-145)
Affinity DataIC50:  1.70nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent