BDBM525499 US11174245, # I-158

SMILES COc1ccccc1-c1cc(ccn1)C(=O)\N=c1/[nH]c2cc(ccc2n1CC(C)(C)O)C1CCN(C1)C(C)=O

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 525499   

TargetEpidermal growth factor receptor [695-1022](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525499(US11174245, # I-158)
Affinity DataIC50:  56.3nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525499(US11174245, # I-158)
Affinity DataIC50:  1.5nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent