BDBM526519 US11186566, Compound 58

SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2C)-n2ccc(OCC3(CCC3)C(F)(F)F)n2)C(C)(C)C1

InChI Key InChIKey=XQRPBALBOHJZSL-IBGZPJMESA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 526519   

TargetCystic fibrosis transmembrane conductance regulator [1-507,509-1480](Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM526519(US11186566, Compound 58)
Affinity DataEC50:  50nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator [1-507,509-1480](Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM526519(US11186566, Compound 58)
Affinity DataEC50: <100nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent