BDBM528332 5-Butyl-3- methyl-9-(1- (trifluoromethyl) cyclopropyl)pyrido [3,2-e][1,2,4] triazolo[4,3- a]pyrazin- 6(5H)-one::US11180503, Example 2

SMILES CCCCn1c2cc(C)cnc2n2c(nnc2c1=O)C1(CC1)C(F)(F)F

InChI Key InChIKey=IGWJBYVNICAEOE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 528332   

LigandPNGBDBM528332(5-Butyl-3- methyl-9-(1- (trifluoromethyl) cyclopro...)
Affinity DataIC50:  8.62nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528332(5-Butyl-3- methyl-9-(1- (trifluoromethyl) cyclopro...)
Affinity DataIC50:  2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM528332(5-Butyl-3- methyl-9-(1- (trifluoromethyl) cyclopro...)
Affinity DataIC50: >1.00E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM528332(5-Butyl-3- methyl-9-(1- (trifluoromethyl) cyclopro...)
Affinity DataIC50: >1.00E+5nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM528332(5-Butyl-3- methyl-9-(1- (trifluoromethyl) cyclopro...)
Affinity DataIC50:  2.60E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528332(5-Butyl-3- methyl-9-(1- (trifluoromethyl) cyclopro...)
Affinity DataIC50:  12.1nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent