BDBM528333 9-([1,1'- Bi(cyclopropan)]- 1-yl)-3- methyl-5- propylpyrido[3,2- e][1,2,4]triazolo[4,3- a]pyrazin-6(5H)-one::US11180503, Example 3
SMILES CCCn1c2cc(C)cnc2n2c(nnc2c1=O)C1(CC1)C1CC1
InChI Key InChIKey=QGLGRZAUXUEFDA-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 528333
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Eli Lilly
US Patent
Eli Lilly
US Patent
Affinity DataIC50: 2.59nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Eli Lilly
US Patent
Eli Lilly
US Patent
Affinity DataIC50: 2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta(Homo sapiens (Human))
Eli Lilly
US Patent
Eli Lilly
US Patent
Affinity DataIC50: >1.00E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
Affinity DataIC50: 2.12E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Eli Lilly
US Patent
Eli Lilly
US Patent
Affinity DataIC50: 3.41nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair