BDBM528353 9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-((2-(trimethylsilyl)ethoxy)methyl)pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazin-6(5H)-one::US11180503, Example 11

SMILES CCCCn1c2cc(CO)cnc2n2c(nnc2c1=O)C1(CC1)C1CC1

InChI Key InChIKey=FLZRLEPPHKZGPK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 528353   

LigandPNGBDBM528353(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-((2-(tri...)
Affinity DataIC50:  0.996nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528353(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-((2-(tri...)
Affinity DataIC50:  2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM528353(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-((2-(tri...)
Affinity DataIC50:  3.85E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM528353(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-((2-(tri...)
Affinity DataIC50: >1.00E+5nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM528353(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-((2-(tri...)
Affinity DataIC50:  5.56E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528353(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-((2-(tri...)
Affinity DataIC50:  0.928nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent