BDBM528597 US11896597, Compound 15
SMILES Clc1cc(ccn1)N1CCN(CCC2CC(=O)C3(C2)CCCCC3)CC1
InChI Key InChIKey=QQXUGQNXDUSQLZ-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 528597
TargetEpidermal growth factor receptor [1-773,'NPH',774-1210](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Affinity DataIC50: 15.1nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-769,'ASV',770-1210](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Affinity DataIC50: 7.5nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Affinity DataIC50: 3.80nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Affinity DataIC50: 0.400nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair