BDBM530357 WO2022064009, Compound 136::WO2022064009, Compound 148

SMILES C[C@@H]1Cc2cnc(NCc3ccn(C)n3)nc2CN1C(=O)[C@@H]1CCN(C)C[C@H]1c1cccc(C)c1

InChI Key InChIKey=YBDRYPNMGCUBKV-FOVJLYNBSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 530357   

TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Janssen Pharmaceutica

WIPO
LigandPNGBDBM530357(WO2022064009, Compound 136 | WO2022064009, Compoun...)
Affinity DataIC50:  11nMAssay Description:Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Compounds with potencies approaching the limit o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Janssen Pharmaceutica

WIPO
LigandPNGBDBM530357(WO2022064009, Compound 136 | WO2022064009, Compoun...)
Affinity DataIC50:  1.38nMAssay Description:Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Janssen Pharmaceutica

WIPO
LigandPNGBDBM530357(WO2022064009, Compound 136 | WO2022064009, Compoun...)
Affinity DataIC50: <9.77nMAssay Description:Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Compounds with potencies approaching the limit o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Janssen Pharmaceutica

WIPO
LigandPNGBDBM530357(WO2022064009, Compound 136 | WO2022064009, Compoun...)
Affinity DataIC50:  16nMAssay Description:Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed