BDBM531233 (Z)-Methyl 3-(((4-(4-(2-((2-hydroxyethyl)amino)-2-oxoethyl)piperazine-1-carbonyl)phenyl)amino)(phenyl)methylene)-5-methyl-2-oxoindoline-6-carboxylate::US11208381, Example 15

SMILES COC(=O)c1cc2N(C(C)=O)C(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCN(CC(=O)OC(C)(C)C)CC3)c3ccccc3)c2cc1C

InChI Key InChIKey=ACCSYFAQPQXJJO-KARKAFJISA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 531233   

TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM531233((Z)-Methyl 3-(((4-(4-(2-((2-hydroxyethyl)amino)-2-...)
Affinity DataKi:  2.5nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM531233((Z)-Methyl 3-(((4-(4-(2-((2-hydroxyethyl)amino)-2-...)
Affinity DataKi:  5nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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US Patent
LigandPNGBDBM531233((Z)-Methyl 3-(((4-(4-(2-((2-hydroxyethyl)amino)-2-...)
Affinity DataKi:  5nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM531233((Z)-Methyl 3-(((4-(4-(2-((2-hydroxyethyl)amino)-2-...)
Affinity DataKi:  5nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
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US Patent
LigandPNGBDBM531233((Z)-Methyl 3-(((4-(4-(2-((2-hydroxyethyl)amino)-2-...)
Affinity DataKi:  7.90nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
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US Patent
LigandPNGBDBM531233((Z)-Methyl 3-(((4-(4-(2-((2-hydroxyethyl)amino)-2-...)
Affinity DataKi:  50nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent