BDBM534393 3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl)-6-chloro-N-(3-(4-chlorophenyl)-2-fluoro-3-hydroxypropyl)-2 -fluorobenzamide enantiomeric mixture 1::WO2022086828, Example 128

SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NC[C@@H](F)[C@H](O)c2ccc(Cl)cc2)c1F

InChI Key InChIKey=WHVHKBUPSUSYAL-OXQOHEQNSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 534393   

TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

WIPO
LigandPNGBDBM534393(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Affinity DataIC50:  1.20nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMixed lineage kinase domain-like protein(Homo sapiens)
Bristol-Myers Squibb

WIPO
LigandPNGBDBM534393(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Affinity DataIC50:  5nMAssay Description:HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed