BDBM535594 5-(3-morpholino-5- (phenylsulfonyl)phenyl)-1,3,4- thiadiazol-2-amine::US11236079, Example 3

SMILES Nc1nnc(s1)-c1cc(N)cc(c1)S(=O)(=O)c1ccccc1

InChI Key InChIKey=VVBPMGGOKDVMFO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535594   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Neuropore Therapies

US Patent
LigandPNGBDBM535594(5-(3-morpholino-5- (phenylsulfonyl)phenyl)-1,3,4- ...)
Affinity DataIC50:  2.20E+3nMAssay Description:Compounds were prepared at 100× final concentration using a 12-point, 1:3 serial-dilution in DMSO, with DMSO control as the 12th point. Compound was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Neuropore Therapies

US Patent
LigandPNGBDBM535594(5-(3-morpholino-5- (phenylsulfonyl)phenyl)-1,3,4- ...)
Affinity DataIC50:  1.60E+3nMAssay Description:The substrate (Phosphatidylinositol (PI): Phosphatidylserine (PS)) was added to freshly prepared reaction buffer (40 mM Tris-HCl (pH7.5), 3 μM O...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent