BDBM536215 (2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one::US11242344, Example 128.3::US11242344, Example 128.4

SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC(C)(N1)c1ccccc1)c1cc(C)no1

InChI Key InChIKey=GCHCNRGXKCLUIW-NOGMPNEWSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 536215   

LigandPNGBDBM536215((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5...)
Affinity DataIC50:  3.36E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536215((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5...)
Affinity DataKd:  5.70E+3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536215((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5...)
Affinity DataIC50:  2.45E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536215((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5...)
Affinity DataIC50:  1.73E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536215((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5...)
Affinity DataKd:  7.50E+3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536215((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5...)
Affinity DataIC50:  1.07E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent