BDBM536256 (2S)-1-((2S,4R)-4-Hydroxy-2-(5-phenyl-5-(trifluoromethyl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one::US11242344, Example 114.1::US11242344, Example 114.3

SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NO[C@@](N1)(c1ccccc1)C(F)(F)F)c1cc(C)no1

InChI Key InChIKey=VNNBFHMSXBWONC-AWQBJMPUSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 536256   

LigandPNGBDBM536256((2S)-1-((2S,4R)-4-Hydroxy-2-(5-phenyl-5-(trifluoro...)
Affinity DataIC50:  4.00E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536256((2S)-1-((2S,4R)-4-Hydroxy-2-(5-phenyl-5-(trifluoro...)
Affinity DataKd:  1.50E+5nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536256((2S)-1-((2S,4R)-4-Hydroxy-2-(5-phenyl-5-(trifluoro...)
Affinity DataIC50:  4.88E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536256((2S)-1-((2S,4R)-4-Hydroxy-2-(5-phenyl-5-(trifluoro...)
Affinity DataIC50:  4.70E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536256((2S)-1-((2S,4R)-4-Hydroxy-2-(5-phenyl-5-(trifluoro...)
Affinity DataKd:  8.80E+3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536256((2S)-1-((2S,4R)-4-Hydroxy-2-(5-phenyl-5-(trifluoro...)
Affinity DataIC50:  1.00E+5nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent