BDBM536271 1-((2S,4R)-2-((R)-5-(2′-fluoro-[1,1′-biphenyl]-4-yl)-5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-4-hydroxypyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one (2 Stereoisomers)::US11242344, Example 139.1
SMILES CC(C)C(C(=O)N1C[C@@H](C[C@H]1C1=NOC(C)(N1)c1ccc(Br)cc1)O[Si](C)(C)C(C)(C)C)c1cc(C)no1
InChI Key InChIKey=ZODMTQOCDYVPAH-ROGCHJSCSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 536271
Affinity DataIC50: 2.17E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
TargetElongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213](Homo sapiens (Human))
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 1.00E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair