BDBM536271 1-((2S,4R)-2-((R)-5-(2′-fluoro-[1,1′-biphenyl]-4-yl)-5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-4-hydroxypyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one (2 Stereoisomers)::US11242344, Example 139.1

SMILES CC(C)C(C(=O)N1C[C@@H](C[C@H]1C1=NOC(C)(N1)c1ccc(Br)cc1)O[Si](C)(C)C(C)(C)C)c1cc(C)no1

InChI Key InChIKey=ZODMTQOCDYVPAH-ROGCHJSCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 536271   

Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536271(1-((2S,4R)-2-((R)-5-(2′-fluoro-[1,1′-b...)
Affinity DataIC50:  2.17E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536271(1-((2S,4R)-2-((R)-5-(2′-fluoro-[1,1′-b...)
Affinity DataIC50:  1.00E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent