BDBM536970 US11896597, Compound 86

SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)nn(-c3nc(cs3)C(O)=O)c2-c2ccc(F)c(c2)-c2ccc(cc2)C2CC2)cc1

InChI Key InChIKey=JBQFQTBCGVLYAE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 536970   

TargetEpidermal growth factor receptor [1-773,'NPH',774-1210](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandPNGBDBM536970(US11896597, Compound 86)
Affinity DataIC50:  21.5nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-769,'ASV',770-1210](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandPNGBDBM536970(US11896597, Compound 86)
Affinity DataIC50:  17.9nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetegfr wt(Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandPNGBDBM536970(US11896597, Compound 86)
Affinity DataIC50:  195nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandPNGBDBM536970(US11896597, Compound 86)
Affinity DataIC50:  9.30nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandPNGBDBM536970(US11896597, Compound 86)
Affinity DataIC50:  0.600nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent