BDBM542545 (1S,3′R,6′R,7′S,8′E,15′R)-6-CHLORO-15′-HYDROXY-7′-METHOXY-N-((2-METHOXYETHYL)SULFONYL)-12′-METHYL-13′-OXO-3,4-DIHYDRO-2H-SPIRO[NAPHTHALENE-1,22′-[20]OXA[1,12]DIAZATETRACYCLO[14.7.2.03,6.019,24]PENTACOSA[8,16,18,24]TETRAENE]-15′-CARBOXAMIDE::US11274105, Example 32

SMILES COCCS(=O)(=O)NC(=O)[C@@]1(O)CC(=O)N(C)CC\C=C\[C@H](OC)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc1cc23

InChI Key InChIKey=ZZCBLGIXBHVKBB-AXEGSQSCSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 542545   

LigandPNGBDBM542545((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataKi:  0.0530nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542545((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataIC50:  0.180nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542545((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataIC50:  2.16nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent