BDBM542579 (3R,6R,7S,11R,17R,24S)-6′-CHLORO-17-HYDROXY-14-METHYL-15-OXO-3′,4′-DIHYDRO-2′H-SPIRO[8,22-DIOXA-1,14-DIAZAPENTACYCLO[16.7.2.17,11.03,6.021,26]OCTACOSA-18,20,26-TRIENE-24,1′-NAPHTHALENE]-17-CARBOXYLIC ACID::US11274105, Example 69::US11274105, Example 70

SMILES CN1CC[C@@H]2CCO[C@@H](C2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)[C@@](O)(CC1=O)C(O)=O

InChI Key InChIKey=XGJAHFCJCSTDNJ-FFAAOZCHSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 542579   

LigandPNGBDBM542579((3R,6R,7S,11R,17R,24S)-6′-CHLORO-17-HYDROXY-...)
Affinity DataKi:  0.0660nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542579((3R,6R,7S,11R,17R,24S)-6′-CHLORO-17-HYDROXY-...)
Affinity DataKi:  0.339nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542579((3R,6R,7S,11R,17R,24S)-6′-CHLORO-17-HYDROXY-...)
Affinity DataIC50:  7.19nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542579((3R,6R,7S,11R,17R,24S)-6′-CHLORO-17-HYDROXY-...)
Affinity DataIC50:  1.07nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542579((3R,6R,7S,11R,17R,24S)-6′-CHLORO-17-HYDROXY-...)
Affinity DataIC50:  31.9nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM542579((3R,6R,7S,11R,17R,24S)-6′-CHLORO-17-HYDROXY-...)
Affinity DataIC50:  0.430nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent