BDBM5491 6-(benzyloxy)-9H-purin-2-amine::CHEMBL407874::O6-Substituted Guanine Deriv. 31

SMILES Nc1nc(OCc2ccccc2)c2[nH]cnc2n1

InChI Key InChIKey=KRWMERLEINMZFT-UHFFFAOYSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 5491   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University of Newcastle

LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50:  2.40E+4nMAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2 [171-432]/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Newcastle

LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50:  3.50E+4nMAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50:  100nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50:  2.60E+3nMAssay Description:In vitro inhibitory activity against human O6-alkylguanine-DNA alkyltransferase (AGAT)More data for this Ligand-Target Pair
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50:  39nMAssay Description:Inhibition of AGT in human HL60 cells assessed as AGT levels using [3H]AGT after 2 hrsMore data for this Ligand-Target Pair
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50:  58nMAssay Description:concentration required to reduce AGT activity to 50% of control rate in intact HT-29 human colorectal carcinoma cellsMore data for this Ligand-Target Pair
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50:  620nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University Of Zurich

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50:  40nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50:  180nMAssay Description:Inhibition of AGT activity to 50% of control rate in HT-29 cell extractMore data for this Ligand-Target Pair