BDBM552370 US11312727, Compound 148BB

SMILES C[C@H]1\C=C\COc2c(F)c(F)ccc2[C@@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1

InChI Key InChIKey=AFXGKACXRBMHKZ-IZAYXBROSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 552370   

TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen Biopharma

US Patent
LigandPNGBDBM552370(US11312727, Compound 148BB)
Affinity DataEC50: >5.00E+3nMAssay Description:Human lung carcinoma A549 cells (ATCC, Manassas, Va.) were plated at a density of 5×104 cells/mL (10×103 cells/well) in assay media (Ham's F12 me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen Biopharma

US Patent
LigandPNGBDBM552370(US11312727, Compound 148BB)
Affinity DataIC50:  6.20nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen Biopharma

US Patent
LigandPNGBDBM552370(US11312727, Compound 148BB)
Affinity DataEC50:  1.40nMAssay Description:Human lung carcinoma A549 cells (ATCC, Manassas, Va.) were plated at a density of 5×104 cells/mL (10×103 cells/well) in assay media (Ham's F12 me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen Biopharma

US Patent
LigandPNGBDBM552370(US11312727, Compound 148BB)
Affinity DataIC50:  470nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent