BDBM558749 Isomer-1 of 4-((3-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-::US11365205, Example 18a

SMILES O[C@@H](CN1CCN(Cc2ccc(cc2)C#N)C1=O)CN1CCc2ccccc2C1

InChI Key InChIKey=BDOGXDDYLRSPFN-JOCHJYFZSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 558749   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM558749(Isomer-1 of 4-((3-(3-(3,4-dihydroisoquinolin-2(1H)...)
Affinity DataIC50:  40nMAssay Description:Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyze mono- and symmetric demethylation on arginine resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent