BDBM558833 3-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-5-fluoro-1-(4-::US11365205, Example 97

SMILES CS(=O)(=O)c1ccc(Cn2c3ccc(F)cc3n(CC(O)CN3CCc4ccccc4C3)c2=O)cc1

InChI Key InChIKey=PNKGVHUHKTWGOK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 558833   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM558833(3-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypr...)
Affinity DataIC50:  40nMAssay Description:Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyze mono- and symmetric demethylation on arginine resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent