BDBM560637 (2R,4R)-1-(3-chloro-2- fluorobenzyl)-4-((5-fluoro- 2-((5-methyl-1H-pyrazol- 3-yl)amino)pyrimidin- 4-yl)methyl)-2- methylpiperidine-4- carboxylic acid::US11384066, Example 26

SMILES C[C@@H]1C[C@@](Cc2nc(Nc3cc(C)[nH]n3)ncc2F)(CCN1Cc1cccc(Cl)c1F)C(O)=O

InChI Key InChIKey=INLLBWVXFCOIDQ-QKFKETGDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 560637   

TargetAurora kinase B(Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM560637((2R,4R)-1-(3-chloro-2- fluorobenzyl)-4-((5-fluoro-...)
Affinity DataIC50:  4.35E+3nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM560637((2R,4R)-1-(3-chloro-2- fluorobenzyl)-4-((5-fluoro-...)
Affinity DataIC50:  2.90nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent