BDBM562228 1-([1,1′-bi(cyclopropan)]-1-yl)-5-butyl-6,7,8,9-tetrahydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one::US11401274, Example 2

SMILES CCCCn1c2CCCCc2n2c(nnc2c1=O)C1(CC1)C1CC1

InChI Key InChIKey=NHHYCGIUZMMXNN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 562228   

LigandPNGBDBM562228(1-([1,1′-bi(cyclopropan)]-1-yl)-5-butyl-6,7,...)
Affinity DataIC50:  3nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM562228(1-([1,1′-bi(cyclopropan)]-1-yl)-5-butyl-6,7,...)
Affinity DataIC50:  4.10nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM562228(1-([1,1′-bi(cyclopropan)]-1-yl)-5-butyl-6,7,...)
Affinity DataIC50: >1.00E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM562228(1-([1,1′-bi(cyclopropan)]-1-yl)-5-butyl-6,7,...)
Affinity DataIC50: >1.00E+5nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM562228(1-([1,1′-bi(cyclopropan)]-1-yl)-5-butyl-6,7,...)
Affinity DataIC50:  1.32E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM562228(1-([1,1′-bi(cyclopropan)]-1-yl)-5-butyl-6,7,...)
Affinity DataIC50:  4.30nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent