BDBM562236 1-(1-cyclopropylcyclopropyl)-5-(cyclopropylmethyl)-3-oxo-7,8-dihydro-5H-pyrano-[1,2,4]triazolo[4,3-a]quinoxalin-4-one::US11401274, Example 6

SMILES O=c1n(CC2CC2)c2COCCc2n2c(nnc12)C1(CC1)C1CC1

InChI Key InChIKey=KPFXUWGXTIMYPE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 562236   

LigandPNGBDBM562236(1-(1-cyclopropylcyclopropyl)-5-(cyclopropylmethyl)...)
Affinity DataIC50:  8.40nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM562236(1-(1-cyclopropylcyclopropyl)-5-(cyclopropylmethyl)...)
Affinity DataIC50:  14.9nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM562236(1-(1-cyclopropylcyclopropyl)-5-(cyclopropylmethyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM562236(1-(1-cyclopropylcyclopropyl)-5-(cyclopropylmethyl)...)
Affinity DataIC50: >1.00E+5nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM562236(1-(1-cyclopropylcyclopropyl)-5-(cyclopropylmethyl)...)
Affinity DataIC50:  3.92E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM562236(1-(1-cyclopropylcyclopropyl)-5-(cyclopropylmethyl)...)
Affinity DataIC50:  5.60nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent