BDBM562398 (rac)-15-chloro-14-ethyl-1-(3-((6-fluoronaphthalen-1-yl)oxy)propyl)-8,13-dimethyl-11-(rac)-morpholino-5,6,9,10,11,13-hexahydro-4H,8H-pyrazolo[3',4':6,7][1]thia[2,10]diazacyclotridecino[8,9,10-hi]indole-2-carboxylic acid 7,7-dioxide (Mixture of Stereoisomers)::US11401278, Example 69
SMILES CCc1c-2c(nn1C)C(CCN(C)S(=O)(=O)CCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13)N1CCOCC1
InChI Key InChIKey=SOSFJVGXMDRHJQ-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 562398
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [173-329]/Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43](Homo sapiens (Human))
The Broad Institute
US Patent
The Broad Institute
US Patent
Affinity DataIC50: 1.5nMAssay Description:MCL-1/Noxa BH3 Peptide (MCL-1 Assay): From there, 50 nl were transferred in a dark test plate (Greiner Bio-One, Frickenhausen, Germany). The assay wa...More data for this Ligand-Target Pair