BDBM565133 BDBM565146::US11414404, Ex. # 10::US11634409, Example 23

SMILES Cc1c(Nc2c(F)ccc(NS(=O)(=O)CCCF)c2Cl)ccc2ncn(C)c(=O)c12

InChI Key InChIKey=VVLVISDSGRHLMB-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 565133   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM565133(BDBM565146 | US11414404, Ex. # 10 | US11634409, Ex...)
Affinity DataIC50:  4.25nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600K](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM565133(BDBM565146 | US11414404, Ex. # 10 | US11634409, Ex...)
Affinity DataIC50:  2.70nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM565133(BDBM565146 | US11414404, Ex. # 10 | US11634409, Ex...)
Affinity DataIC50:  3.25nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600K](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM565133(BDBM565146 | US11414404, Ex. # 10 | US11634409, Ex...)
Affinity DataIC50:  2.70nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM565133(BDBM565146 | US11414404, Ex. # 10 | US11634409, Ex...)
Affinity DataIC50:  4.25nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600K](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM565133(BDBM565146 | US11414404, Ex. # 10 | US11634409, Ex...)
Affinity DataIC50:  2.70nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM565133(BDBM565146 | US11414404, Ex. # 10 | US11634409, Ex...)
Affinity DataIC50:  3.25nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600K](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM565133(BDBM565146 | US11414404, Ex. # 10 | US11634409, Ex...)
Affinity DataIC50:  2.70nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
In DepthDetails US Patent