BDBM567800 US11420968, Example F43

SMILES CC(C)c1ccccc1[C@@H]1CCCN1C1CC2(C1)CCN(CC2)c1ccc(C(=O)NS(=O)(=O)c2ccc(NC[C@H]3CC[C@](C)(O)CC3)c(c2)[N+]([O-])=O)c(Oc2cnc3[nH]ccc3c2)c1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 567800   

TargetApoptosis regulator Bcl-2 [G101V](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM567800(US11420968, Example F43)
Affinity DataIC50:  0.420nMAssay Description:Selected compounds disclosed herein were tested for blocking of Bcl-2-G101 protein with its ligand in an assay based on time-resolved fluorescence re...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM567800(US11420968, Example F43)
Affinity DataIC50: >3.00E+4nMAssay Description:The five isoform-selective probe substrate (in a cocktail manner) was used as a measure of activity for the individual cytochrome P450 (CYPs) in a po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM567800(US11420968, Example F43)
Affinity DataIC50:  18nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2 [G101V](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM567800(US11420968, Example F43)
Affinity DataIC50:  0.0150nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In DepthDetails US Patent