BDBM571425 3-{(3E)-3-[1-(3- chlorobenzoyl)-3,3- dimethylpiperidin-4- ylidene]prop-1-yn-1- yl}benzonitrile::US11440922, Example 116

SMILES CC1(C)CN(CC\C1=C/C#Cc1cccc(c1)C#N)C(=O)c1cccc(Cl)c1

InChI Key InChIKey=SDCJSFLZVCKWHF-UFFVCSGVSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 571425   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571425(3-{(3E)-3-[1-(3- chlorobenzoyl)-3,3- dimethylpiper...)
Affinity DataKi:  1.60nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571425(3-{(3E)-3-[1-(3- chlorobenzoyl)-3,3- dimethylpiper...)
Affinity DataEC50:  52.8nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent