BDBM571539 (rac)-17-chloro-1-ethyl-14-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-3b,4,5,6,8,9,10,11-octahydro-2H-pyrazolo[3′,4′:8,9]pyrrolo[1′,2′:6,7][1,6]diazacycloundecino[10,11,1-hi]indole-13-carboxylic Acid (Isomer 1, Diasteromer of Example 107)::US11440923, Example 104
SMILES CCc1c-2c(nn1C)C1CCCN1CCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13
InChI Key InChIKey=AGLLPJYSQPPHJN-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 571539
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide(Homo sapiens (Human))
Bayer Aktiengesellschaft
US Patent
Bayer Aktiengesellschaft
US Patent
Affinity DataIC50: 0.880nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair