BDBM572231 3-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- pyrrolo[2,3-b]pyridin-3-yl]-1,2,4-thiadiazole::US11447505, Example E116::US11447505, Example E236

SMILES C1CCC2(CCCN(C2)c2ccnc3[nH]cc(-c4nc[nH]n4)c23)NC1

InChI Key InChIKey=MNTJTGDDVMAAQV-SSZFMOIBSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 572231   

TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572231(3-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...)
Affinity DataKi:  0.0120nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase MRCK beta(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572231(3-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...)
Affinity DataKi:  0.0120nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase MRCK beta(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572231(3-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...)
Affinity DataKi:  0.0900nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572231(3-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...)
Affinity DataKi:  0.0950nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572231(3-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...)
Affinity DataKi:  39.4nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572231(3-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...)
Affinity DataKi:  85.1nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572231(3-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...)
Affinity DataKi:  105nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572231(3-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...)
Affinity DataKi:  390nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent