BDBM572233 (6S)-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)- 1,8-diazaspiro[5.5]undecane::US11447505, Example E117::US11447505, Example E168

SMILES C1CCC2(CCCN(C2)c2ccnc3[nH]cc(-c4ccncn4)c23)NC1

InChI Key

Data  7 KI

PDB links: 1 PDB ID matches this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 572233   

TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572233((6S)-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridin-...)
Affinity DataKi:  0.0140nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetSerine/threonine-protein kinase MRCK beta(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572233((6S)-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridin-...)
Affinity DataKi:  0.0230nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase MRCK beta(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572233((6S)-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridin-...)
Affinity DataKi:  0.0650nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572233((6S)-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridin-...)
Affinity DataKi:  5.38nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572233((6S)-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridin-...)
Affinity DataKi:  18.4nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572233((6S)-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridin-...)
Affinity DataKi:  30.9nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572233((6S)-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridin-...)
Affinity DataKi:  89nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent