BDBM572276 4-(1-ethyl-1,8-diazaspiro[5.5]undecan-8-yl)-1H- pyrrolo[2,3-b]pyridine-3-carbonitrile::US11447505, Example E211

SMILES CCN1CCCCC11CCCN(C1)c1ccnc2[nH]cc(C#N)c12

InChI Key

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 572276   

TargetSerine/threonine-protein kinase MRCK beta(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572276(4-(1-ethyl-1,8-diazaspiro[5.5]undecan-8-yl)-1H- py...)
Affinity DataKi:  0.351nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572276(4-(1-ethyl-1,8-diazaspiro[5.5]undecan-8-yl)-1H- py...)
Affinity DataKi:  0.631nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572276(4-(1-ethyl-1,8-diazaspiro[5.5]undecan-8-yl)-1H- py...)
Affinity DataKi:  34.3nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572276(4-(1-ethyl-1,8-diazaspiro[5.5]undecan-8-yl)-1H- py...)
Affinity DataKi:  245nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent