BDBM572320 (3S)-N-methyl-1-[3-(1H- pyrazol-3-yl)-1H- pyrrolo[2,3-b]pyridin-4- yl]piperidin-3-amine::US11447505, Example E83

SMILES CN[C@H]1CCCN(C1)c1ccnc2[nH]cc(-c3cc[nH]n3)c12

InChI Key InChIKey=VZCANWJUAWDDCO-UMAGAQSHSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 572320   

TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572320((3S)-N-methyl-1-[3-(1H- pyrazol-3-yl)-1H- pyrrolo[...)
Affinity DataKi:  0.481nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase MRCK beta(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572320((3S)-N-methyl-1-[3-(1H- pyrazol-3-yl)-1H- pyrrolo[...)
Affinity DataKi:  1.85nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM572320((3S)-N-methyl-1-[3-(1H- pyrazol-3-yl)-1H- pyrrolo[...)
Affinity DataKi:  196nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent