BDBM573245 US11453683, Example 12::US20230279025, Example 12
SMILES Oc1cc(-c2ncc3c(nc(OC[C@@H]4CCCN4Cc4ccccc4)nc3c2F)N2CC3CCC(C2)N3)c2ccccc2c1
InChI Key InChIKey=CZZTVFHEYQWJOC-WNMGUVTHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 573245
Affinity DataKd: 11nMAssay Description:Briefly, 1L of 1.05X HBS-Mg buffer (262.5 mM Bioultra Hepes, pH 7.5, 157.5 mM NaCl, 105 mM MgCl2, 0.525 mM TCEP, 0.0305% Brij-35) was prepared and fi...More data for this Ligand-Target Pair
Affinity DataIC50: 4.91E+3nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Table 1: Briefly, 1 L of 1.05× HBS-Mg buffer (262.5 mM Bioultra Hepes, pH 7.5, 157.5 mM NaCl, 105 mM MgCl2, 0.525 mM TCEP, 0.0305% Brij-35) was prepa...More data for this Ligand-Target Pair