BDBM577095 10-(4-Chlorophenyl)-2-cyclopropyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one ::US11472805, Example 12

SMILES Clc1ccc(cc1)-c1c2C(=O)N(CCn2c2ccccc12)C1CC1

InChI Key InChIKey=PJUUZPXCNUJBPS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 577095   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577095(10-(4-Chlorophenyl)-2-cyclopropyl-3,4-dihydropyraz...)
Affinity DataIC50:  12nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577095(10-(4-Chlorophenyl)-2-cyclopropyl-3,4-dihydropyraz...)
Affinity DataIC50:  3.09E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577095(10-(4-Chlorophenyl)-2-cyclopropyl-3,4-dihydropyraz...)
Affinity DataIC50:  23.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577095(10-(4-Chlorophenyl)-2-cyclopropyl-3,4-dihydropyraz...)
Affinity DataIC50:  19.2nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent