BDBM577120 5-(8-Cyclopropyl-9-oxo-6,7,8,9-tetrahydropyrido[2',3':4,5]pyrrolo[1,2-a]pyrazin-10-yl)pyridine-2-carbonitrile::US11472805, Example 26

SMILES O=C1N(CCn2c1c(-c1ccc(nc1)C#N)c1ncccc21)C1CC1

InChI Key InChIKey=SEPBFTDLZPYNPJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 577120   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577120(5-(8-Cyclopropyl-9-oxo-6,7,8,9-tetrahydropyrido[2'...)
Affinity DataIC50:  8.15nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577120(5-(8-Cyclopropyl-9-oxo-6,7,8,9-tetrahydropyrido[2'...)
Affinity DataIC50:  138nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577120(5-(8-Cyclopropyl-9-oxo-6,7,8,9-tetrahydropyrido[2'...)
Affinity DataIC50:  14.8nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577120(5-(8-Cyclopropyl-9-oxo-6,7,8,9-tetrahydropyrido[2'...)
Affinity DataIC50:  2.98nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent