BDBM577121 9-(4-Chlorophenyl)-7-cyclopropyl-6,7-dihydro[1,3]thiazolo[4',5':4,5]pyrrolo[1,2-a]pyrazin-8(5H)-one::US11472805, Example 27

SMILES Clc1ccc(cc1)-c1c2C(=O)N(CCn2c2scnc12)C1CC1

InChI Key InChIKey=IMNGGIXQGKWJJB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 577121   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577121(9-(4-Chlorophenyl)-7-cyclopropyl-6,7-dihydro[1,3]t...)
Affinity DataIC50:  2.28nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577121(9-(4-Chlorophenyl)-7-cyclopropyl-6,7-dihydro[1,3]t...)
Affinity DataIC50:  434nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577121(9-(4-Chlorophenyl)-7-cyclopropyl-6,7-dihydro[1,3]t...)
Affinity DataIC50:  9.03nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577121(9-(4-Chlorophenyl)-7-cyclopropyl-6,7-dihydro[1,3]t...)
Affinity DataIC50:  3.04nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent