BDBM577127 8-Cyclopropyl-10-(3,4-dimethylphenyl)-7,8-dihydropyrido[2',3':4,5]pyrrolo[1,2-a]pyrazin-9(6H)-one::US11472805, Example 33

SMILES Cc1ccc(cc1C)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1

InChI Key InChIKey=LAJDTVWSQMUYRE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 577127   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577127(8-Cyclopropyl-10-(3,4-dimethylphenyl)-7,8-dihydrop...)
Affinity DataIC50:  4.93nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577127(8-Cyclopropyl-10-(3,4-dimethylphenyl)-7,8-dihydrop...)
Affinity DataIC50:  497nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577127(8-Cyclopropyl-10-(3,4-dimethylphenyl)-7,8-dihydrop...)
Affinity DataIC50:  11.2nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577127(8-Cyclopropyl-10-(3,4-dimethylphenyl)-7,8-dihydrop...)
Affinity DataIC50:  6.09nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent