BDBM578954 US11479551, Example 13-1::US11479551, Example 6-2::US11479551, Example 6-3::US11479551, Example 6-4::US11492351, Example 13-1

SMILES Brc1ccc2c(CN3C(=O)c4ccccc4C3=O)n[nH]c(=O)c2c1

InChI Key InChIKey=WXJCLFKZPXBVLQ-UHFFFAOYSA-N

Data  16 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 578954   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50:  8.96E+4nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50:  9.40E+3nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50:  1.90E+4nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

In DepthDetails US Patent
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50:  0nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50:  2.50E+4nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

In DepthDetails US Patent
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50:  8.96E+4nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

In DepthDetails US Patent
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50:  9.40E+3nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50:  1.90E+4nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50:  0nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50:  2.50E+4nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM578954(US11479551, Example 13-1 | US11479551, Example 6-2...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI