BDBM580875 5-(3-((difluoro(phenyl)methyl)sulfonyl)-5- morpholinophenyl)pyrimidin-2-amine::US11492348, Compound 87

SMILES Nc1ncc(cn1)-c1cc(cc(c1)S(=O)(=O)C(F)(F)c1ccccc1)N1CCOCC1

InChI Key InChIKey=LAYSHJBZMVAZOG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 580875   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Neuropore Therapies

US Patent
LigandPNGBDBM580875(5-(3-((difluoro(phenyl)methyl)sulfonyl)-5- morphol...)
Affinity DataIC50:  210nMAssay Description:Quantification of ATP to ADP conversion as a measure of PI3Kα activity. Active PI3Kα (Life Technologies), in the presence or absence of PI3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Neuropore Therapies

US Patent
LigandPNGBDBM580875(5-(3-((difluoro(phenyl)methyl)sulfonyl)-5- morphol...)
Affinity DataIC50:  1.44E+3nMAssay Description:The substrate was prepared in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase [1-472,474-480](Homo sapiens (Human))
Neuropore Therapies

US Patent
LigandPNGBDBM580875(5-(3-((difluoro(phenyl)methyl)sulfonyl)-5- morphol...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of the PI3K-AKT-mTOR pathway was measured by quantifying the loss of (Ser-473) pAKT using AlphaScreen (Perkin Elmer). B103 (Rat Neuroblast...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent