BDBM581323 US11504381, Compound 6::US11548866, Compound 6

SMILES CC1CN(C(CN1C(=O)CC(O)=O)c1ccc(Cl)cc1)c1ncc(Cl)cc1N

InChI Key InChIKey=JYUNRNBZECUCAS-UHFFFAOYSA-N

Data  2 KI  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 581323   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Ligature Therapeutics

US Patent
LigandPNGBDBM581323(US11504381, Compound 6 | US11548866, Compound 6)
Affinity DataKi:  6.80E+4nMAssay Description:The compounds binding to MDM2 were determined by a quantitative fluorescence polarization binding assay using a recombinant MDM2 protein and fluoresc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Ligature Therapeutics

US Patent
LigandPNGBDBM581323(US11504381, Compound 6 | US11548866, Compound 6)
Affinity DataKi:  6.80E+4nMAssay Description:The compounds binding to MDM2 were determined by a quantitative fluorescence polarization binding assay using a recombinant MDM2 protein and fluoresc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Ligature Therapeutics

US Patent
LigandPNGBDBM581323(US11504381, Compound 6 | US11548866, Compound 6)
Affinity DataKd:  3.40E+4nMAssay Description:ITC experiments were run on a Malvern MicroCal Auto-ITC200 or ITC200 machine. Titration experiments were run in 20 mM Phosphate, 150 mM NaCl and 1 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Ligature Therapeutics

US Patent
LigandPNGBDBM581323(US11504381, Compound 6 | US11548866, Compound 6)
Affinity DataKd:  3.40E+4nMAssay Description:ITC experiments were run on a Malvern MicroCal Auto-ITC200 or ITC200 machine. Titration experiments were run in 20 mM Phosphate, 150 mM NaCl and 1 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent