BDBM588252 1-N-[4-(7-carbamoylquinolin- 4-yl)oxyphenyl]-1-N'-(4- fluorophenyl)cyclopropane- 1,1-dicarboxamide::US11542259, Compound 164

SMILES NC(=O)c1ccc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)ccnc2c1

InChI Key InChIKey=KIRFCVRSKXKWBJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 588252   

TargetTyrosine-protein kinase receptor UFO [473-894,Q764R](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM588252(1-N-[4-(7-carbamoylquinolin- 4-yl)oxyphenyl]-1-N'-...)
Affinity DataIC50: <10nMAssay Description:Human Axl (residues H473-A894 with Q764R, 161 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG (SEO ID NO. 43) 10 mM m...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM588252(1-N-[4-(7-carbamoylquinolin- 4-yl)oxyphenyl]-1-N'-...)
Affinity DataIC50: <10nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEO ID NO...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer [557-882,H628Q,R794A](Tyrosine-protein kinase Mer)
Exelixis

US Patent
LigandPNGBDBM588252(1-N-[4-(7-carbamoylquinolin- 4-yl)oxyphenyl]-1-N'-...)
Affinity DataIC50: <10nMAssay Description:Human Mer (residues R557-E882 with H628Q and R794A, 0.7 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl, 250 μM GGMEDIYFEFMGGKK...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent