BDBM597757 US11608319, Compound 5

SMILES NCC(Oc1ccc(cc1)C(F)(F)F)C(=O)Nc1ccc(cc1)-c1cn[nH]c1

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 597757   

TargetRho-associated protein kinase 1(Homo sapiens (Human))
Industrial Technology Research Institute

US Patent
LigandPNGBDBM597757(US11608319, Compound 5)
Affinity DataIC50:  5.5nMAssay Description:Table 2: Inhibitory effect of each compound synthesized above on Rho-associated protein kinase (ROCK) was tested.Method 1. 10 mM test compound was di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 19(Homo sapiens (Human))
Industrial Technology Research Institute

US Patent
LigandPNGBDBM597757(US11608319, Compound 5)
Affinity DataIC50: >1.00E+4nMAssay Description:Table 5: The experimental procedure referred to the Z′-LYTE Screening Protocol and Assay Conditions provided by ThermoFisher Scientific. C-1. M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase family member 4(Homo sapiens (Human))
Industrial Technology Research Institute

US Patent
LigandPNGBDBM597757(US11608319, Compound 5)
Affinity DataIC50:  550nMAssay Description:Table 4: Assay for Inhibitory Effect on Myosin Light Chain Kinase 4 (MYLK-4). The experimental procedure referred to the LanthaScreen Eu Kinase Bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent