BDBM601950 7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 52

SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1

InChI Key InChIKey=ZPHBEDTYTQWLFC-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 601950   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601950(7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amin...)
Affinity DataIC50:  18nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601950(7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amin...)
Affinity DataIC50:  4.5nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601950(7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amin...)
Affinity DataIC50:  27nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601950(7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amin...)
Affinity DataIC50:  75nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601950(7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amin...)
Affinity DataIC50: >1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601950(7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amin...)
Affinity DataIC50:  242nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601950(7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amin...)
Affinity DataIC50:  75nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601950(7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amin...)
Affinity DataIC50:  84nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM601950(7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amin...)
Affinity DataIC50:  318nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent