BDBM606262 US11685719, Example 28A::US11685719, Example 28B

SMILES Cc1cnc(COc2cc(C)n(-c3cc(ncc3C)-n3ccnc(c3=O)C(C)(C)O)c(=O)c2Cl)c(F)c1

InChI Key InChIKey=MKHGLLWUWDYQIR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 606262   

TargetMitogen-activated protein kinase 14/1(Homo sapiens (Human))
Xinthera

US Patent
LigandPNGBDBM606262(US11685719, Example 28A | US11685719, Example 28B)
Affinity DataIC50:  1nMAssay Description:A typical assay was conducted in 20 μL volume including 60 μM active p38α (Carna, cat #04-152), 10 μM ATP, 1 μM FITC-HSP27 p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM606262(US11685719, Example 28A | US11685719, Example 28B)
Affinity DataIC50: >3.16E+5nMAssay Description:A typical assay was conducted in 20 μL volume including 60 μM active p38α (Carna, cat #04-152), 10 μM ATP, 1 μM FITC-HSP27 p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14/1(Homo sapiens (Human))
Xinthera

US Patent
LigandPNGBDBM606262(US11685719, Example 28A | US11685719, Example 28B)
Affinity DataIC50: >100nMAssay Description:A typical assay was conducted in 20 μL volume including 60 μM active p38α (Carna, cat #04-152), 10 μM ATP, 1 μM FITC-HSP27 p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM606262(US11685719, Example 28A | US11685719, Example 28B)
Affinity DataIC50:  3.16E+3nMAssay Description:A typical assay was conducted in 20 μL volume including 60 μM active p38α (Carna, cat #04-152), 10 μM ATP, 1 μM FITC-HSP27 p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent