BDBM608817 US11702411, Compound 1::US11702411, Example 1

SMILES N[C@@H]1CCCC11CCN(CC1)c1ncc(nc1CO)-c1ccnc(Cl)c1Cl

InChI Key InChIKey=HSLSZACYMZYPEX-OAHLLOKOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 608817   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM608817(US11702411, Compound 1 | US11702411, Example 1)
Affinity DataIC50:  275nMAssay Description:The inhibition of SHP2 by compounds of the present disclosure (concentrations varying from 0.00005-10 μM) was monitored using an assay in which ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM608817(US11702411, Compound 1 | US11702411, Example 1)
Affinity DataIC50:  145nMAssay Description:The inhibition of SHP2 by compounds of the present disclosure (concentrations varying from 0.00005-10 μM) was monitored using an assay in which ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent