BDBM6131 US8802686, 1::US8802686, C1

SMILES C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)S(=O)(=O)C2CC2)ncc1C(F)(F)F

InChI Key InChIKey=BAOWDLOLYGOWOE-GHMZBOCLSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 6131   

TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6131(US8802686, 1 | US8802686, C1)
Affinity DataIC50:  8nMpH: 8.0 T: 2°CAssay Description:CDK1/CycB (200 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 and within the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6131(US8802686, 1 | US8802686, C1)
Affinity DataIC50:  6nMpH: 8.0 T: 2°CAssay Description:CDK2/CycE (50 mg/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 uM, and within ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6131(US8802686, 1 | US8802686, C1)
Affinity DataIC50:  52nMpH: 7.0 T: 2°CAssay Description:Recombinant CDK4 and CycD1-GST fusion proteins, purified from baculovirus-infected insect cells (Sf9), were purchased from ProQinase GmbH, Freiburg. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6131(US8802686, 1 | US8802686, C1)
Affinity DataIC50:  260nMpH: 5.5 T: 2°CAssay Description:VEGF receptor tyrosine kinase (90 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substance...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6131(US8802686, 1 | US8802686, C1)
Affinity DataIC50:  16nMpH: 8.0 T: 2°CAssay Description:CDK1/CycB (200 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 and within the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6131(US8802686, 1 | US8802686, C1)
Affinity DataIC50:  16nMpH: 8.0 T: 2°CAssay Description:CDK2/CycE (50 mg/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 uM, and within ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6131(US8802686, 1 | US8802686, C1)
Affinity DataIC50:  20nMpH: 7.0 T: 2°CAssay Description:Recombinant CDK4 and CycD1-GST fusion proteins, purified from baculovirus-infected insect cells (Sf9), were purchased from ProQinase GmbH, Freiburg. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6131(US8802686, 1 | US8802686, C1)
Affinity DataIC50:  51nMpH: 5.5 T: 2°CAssay Description:VEGF receptor tyrosine kinase (90 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substance...More data for this Ligand-Target Pair
In DepthDetails US Patent